Treatment of severe Clonorchiasis sinensis by endoscopic nasobiliary drainage and oral praziquantel.

Aim: To assess the therapeutic value of endoscopic nasobiliary drainage (ENBD) and oral praziquantel for severe Clonorchiasis sinensis infection.
Methods: Of the 84 Clonorchiasis sinensis-infected patients enrolled, 58 were treated with ENBD (as observing group, ENBD group), 26 received operations (control group, operation group). Both of the two groups were comparable in terms of patient's age, body mass index. Before and one week after treatment, the average diameters of common bile ducts were measured by ultrasound, and serum bilirubin, ALP, gamma-GT and ALT were detected by biochemical methods. After ENBD or operation, the patients took praziquantel for two days.
Results: Compared with the patients in operation group, ENBD patients in ENBD group had higher recovery rates of abdominal pain and fever as well as jaundice, quicker remission, smaller trauma, fewer complications and lower cost.
Conclusion: ENBD combined with oral praziquantel is an effective and safe method for the treatment of severe Clonorchiasis sinensis.