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Childhood adversity, monoamine oxidase a genotype, and risk for conduct disorder.
- Source :
-
Archives of general psychiatry [Arch Gen Psychiatry] 2004 Jul; Vol. 61 (7), pp. 738-44. - Publication Year :
- 2004
-
Abstract
- Background: Very little is known about how different sets of risk factors interact to influence risk for psychiatric disorder.<br />Objective: To replicate a recent report of a genotype-environment interaction that predicts risk for antisocial behavior in boys.<br />Design: Characterizing risk for conduct disorder in boys in association with monoamine oxidase A genotype and exposure to familial adversity, defined by interparental violence, parental neglect, and inconsistent discipline.<br />Setting: A community-based sample of twin boys.<br />Participants: Five hundred fourteen male twins aged 8 to 17 years.<br />Main Outcome Measure: Conduct disorder.<br />Results: There was a main effect of adversity but not of monoamine oxidase A on risk for conduct disorder. Low monoamine oxidase A activity increased risk for conduct disorder only in the presence of an adverse childhood environment. Neither a passive nor an evocative genotype-environment correlation accounted for the interaction.<br />Conclusion: This study replicates a recent report of a genotype-environment interaction that predicts individual variation in risk for antisocial behavior in boys.
- Subjects :
- Adolescent
Antisocial Personality Disorder diagnosis
Antisocial Personality Disorder epidemiology
Antisocial Personality Disorder genetics
Child
Child Abuse diagnosis
Child Abuse psychology
Child Abuse statistics & numerical data
Child of Impaired Parents psychology
Child of Impaired Parents statistics & numerical data
Conduct Disorder diagnosis
Conduct Disorder genetics
Diseases in Twins diagnosis
Diseases in Twins genetics
Domestic Violence psychology
Genetic Predisposition to Disease
Genotype
Humans
Life Change Events
Male
Risk Factors
Sex Factors
Social Environment
Virginia epidemiology
Conduct Disorder epidemiology
Diseases in Twins epidemiology
Domestic Violence statistics & numerical data
Monoamine Oxidase genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0003-990X
- Volume :
- 61
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Archives of general psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 15237086
- Full Text :
- https://doi.org/10.1001/archpsyc.61.7.738