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Obesity reveals an association between blood pressure and the G-protein beta3-subunit gene: a study of female dizygotic twins.
- Source :
-
Pharmacogenetics [Pharmacogenetics] 2004 Jul; Vol. 14 (7), pp. 419-27. - Publication Year :
- 2004
-
Abstract
- The 825C>T polymorphism of the G-protein beta3-subunit gene (GNB3) has been associated with hypertension, although results are not entirely consistent. In a sample of 282 female Caucasian dizygotic twins aged 21-80 years, we aimed to investigate the associations between blood pressure and five single nucleotide polymorphisms (SNPs) including the 825C>T and haplotypes of the GNB3 gene. The polymorphisms (-350A>G, 657A>T, 814G>A, 825C>T and 1429C>T) were genotyped by polymerase chain reaction-restriction enzyme assays. Regular association tests did not show a significant effect on blood pressure for any of the five SNPs. However, strongly significant interactions between the -350A>G, 825C>T and 1429C>T loci and adiposity (both body mass index and waist circumference) were observed for systolic blood pressure (Ps < 0.01) as well as diastolic blood pressure (Ps < 0.05), suggesting increases in adiposity amplify the effects of the SNPs on blood pressure. Haplotype analyses confirmed the effects of the GNB3 gene-obesity interaction on hypertension risk. Additionally, sib-transmission disequilibrium tests (sib-TDTs) showed significant associations with blood pressure for the 825C>T and 1429C>T loci. In summary, the presence of obesity reveals an association between blood pressure and the GNB3 gene in White females. Our data suggest that adiposity is a final pathway through which gene-lifestyle interactions may exert their effects on the development of hypertension. Our results from the combined SNP, haplotype and sib-TDT analyses also support the hypothesis that the 825C>T is a susceptibility locus for hypertension, whereas effects of other loci on blood pressure may result from their strong linkage disequilibrium with the 825C>T locus.
- Subjects :
- Adult
Aged
Aged, 80 and over
Body Mass Index
Body Size
Female
Humans
Hypertension epidemiology
Middle Aged
Risk Factors
Twins, Dizygotic
White People genetics
Blood Pressure physiology
Heterotrimeric GTP-Binding Proteins genetics
Hypertension genetics
Obesity genetics
Polymorphism, Single Nucleotide genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0960-314X
- Volume :
- 14
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Pharmacogenetics
- Publication Type :
- Academic Journal
- Accession number :
- 15226674
- Full Text :
- https://doi.org/10.1097/01.fpc.0000114748.08559.ad