Fluorinated quinoid inhibitor: possible "pure" arylator predicted by the simple theoretical calculation.

Authors :: Ham SW
Choe JI
Wang MF
Peyregne V
Carr BI
Source :: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2004 Aug 02; Vol. 14 (15), pp. 4103-5.
Publication Year :: 2004
Abstract: We report on the fluorinated form of Cpd 5 as a cell growth inhibitor. This compound is 3-fold more potent than the parent Cpd 5 and is predicted, using the semi-empirical AM1 method to be only an arylator of cysteine-containing proteins, without generating reactive oxygen species.

Subjects :: Benzoquinones chemical synthesis
Benzoquinones pharmacology
Fluorides antagonists & inhibitors
Models, Theoretical
Naphthoquinones chemical synthesis
Naphthoquinones pharmacology
Structure-Activity Relationship
Hydroquinones antagonists & inhibitors

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