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Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study.
- Source :
-
Breast cancer research : BCR [Breast Cancer Res] 2004; Vol. 6 (4), pp. R352-65. Date of Electronic Publication: 2004 May 07. - Publication Year :
- 2004
-
Abstract
- Introduction: Breast cancer risk may be determined by various genetic, metabolic, and lifestyle factors that alter sex hormone metabolism. Cytochrome P450 1A2 (CYP1A2) is responsible for the metabolism of estrogens and many exogenous compounds, including caffeine.<br />Methods: In a cross-sectional study of 146 premenopausal and 149 postmenopausal women, we examined the relationships between CYP1A2 activity and known or suspected risk factors for breast cancer. Blood levels of sex hormones, lipids, and growth factors were measured. In vivo CYP1A2 activity was assessed by measuring caffeine metabolites in urine. Stepwise and maximum R regression analyses were used to identify covariates related to CYP1A2 activity after adjustment for ethnicity.<br />Results: In both menopausal groups CYP1A2 activity was positively related to smoking and levels of sex hormone binding globulin. In premenopausal women, CYP1A2 activity was also positively related to insulin levels, caffeine intake, age, and plasma triglyceride levels, and negatively related with total cholesterol levels and body mass index. In postmenopausal women CYP1A2 activity was positively associated with insulin-like growth factor-1, and negatively associated with plasma triglyceride, high-density lipoprotein cholesterol, and age at menarche.<br />Conclusion: These results suggest that CYP1A2 activity is correlated with hormones, blood lipids, and lifestyle factors associated with breast cancer risk, although some of the observed associations were contrary to hypothesized directions and suggest that increased CYP1A2 function may be associated with increased risk for breast cancer.
- Subjects :
- Adult
Age Factors
Body Weight physiology
Breast Neoplasms blood
Breast Neoplasms ethnology
Breast Neoplasms genetics
Cross-Sectional Studies
Ethnicity
Female
Gonadal Steroid Hormones blood
Humans
Insulin blood
Insulin-Like Growth Factor I metabolism
Life Style ethnology
Lipids blood
Middle Aged
Parity physiology
Postmenopause blood
Predictive Value of Tests
Premenopause blood
Risk Factors
Breast Neoplasms enzymology
Cytochrome P-450 CYP1A2 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1465-542X
- Volume :
- 6
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Breast cancer research : BCR
- Publication Type :
- Academic Journal
- Accession number :
- 15217502
- Full Text :
- https://doi.org/10.1186/bcr798