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Multiserotype protection of mice against pneumococcal colonization of the nasopharynx and middle ear by killed nonencapsulated cells given intranasally with a nontoxic adjuvant.
- Source :
-
Infection and immunity [Infect Immun] 2004 Jul; Vol. 72 (7), pp. 4290-2. - Publication Year :
- 2004
-
Abstract
- Intranasal challenge of C57BL/6 mice with Streptococcus pneumoniae serotypes 6B, 14, and 23F produced colonization of the middle ear and NP. Intranasal vaccination with ethanol-killed nonencapsulated cells with adjuvant protected both sites. Of four nontoxic adjuvants tested, the cholera toxin B subunit was most effective and least nonspecifically protective.
- Subjects :
- Adjuvants, Immunologic pharmacology
Animals
Ear Diseases immunology
Ear Diseases prevention & control
Ear, Middle immunology
Ear, Middle microbiology
Mice
Nasopharyngeal Diseases immunology
Nasopharyngeal Diseases prevention & control
Pneumococcal Infections prevention & control
Pneumococcal Vaccines pharmacology
Serotyping
Streptococcus pneumoniae drug effects
Ear Diseases microbiology
Nasopharyngeal Diseases microbiology
Pneumococcal Infections immunology
Pneumococcal Vaccines immunology
Streptococcus pneumoniae immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0019-9567
- Volume :
- 72
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 15213177
- Full Text :
- https://doi.org/10.1128/IAI.72.7.4290-4292.2004