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Thalidomide neurotoxicity: prospective study in patients with lupus erythematosus.
- Source :
-
Neurology [Neurology] 2004 Jun 22; Vol. 62 (12), pp. 2288-90. - Publication Year :
- 2004
-
Abstract
- The authors prospectively followed 14 patients treated with thalidomide for cutaneous lupus erythematosus (CLE), in order to evaluate the occurrence of peripheral neuropathy (PN) and to assess whether PN correlates with thalidomide dose. The patients were followed for up to 24 months with neurologic and electrophysiologic evaluations. Seven patients (50%) developed sensory axonal PN. The median time free from PN was 14 months. PN occurred after 10 months in the majority of patients. No correlations were found between thalidomide cumulative dose and occurrence of PN (Mann-Whitney U test; p > 0.16).
- Subjects :
- Adult
Electrophysiology
Humans
Immunosuppressive Agents administration & dosage
Immunosuppressive Agents therapeutic use
Middle Aged
Neurotoxicity Syndromes diagnosis
Peripheral Nervous System Diseases diagnosis
Prospective Studies
Thalidomide administration & dosage
Thalidomide therapeutic use
Immunosuppressive Agents adverse effects
Lupus Erythematosus, Cutaneous drug therapy
Neurotoxicity Syndromes etiology
Peripheral Nervous System Diseases chemically induced
Thalidomide adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1526-632X
- Volume :
- 62
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 15210897
- Full Text :
- https://doi.org/10.1212/01.wnl.0000130499.91775.2c