Back to Search
Start Over
Effect of acute marijuana on cardiovascular function and central nervous system pharmacokinetics of [(15)O]water: effect in occasional and chronic users.
- Source :
-
Journal of clinical pharmacology [J Clin Pharmacol] 2004 Jul; Vol. 44 (7), pp. 751-66. - Publication Year :
- 2004
-
Abstract
- The objective of this study was to evaluate the effect of the acute administration of marijuana (MJ) on cardiovascular (CV) function and CNS pharmacokinetics (PK) of [(15)O]water in occasional (O) versus chronic (C) MJ users. Each subject received four injections of [(15)O]water (one prior and three postsmoking) on two occasions in which they received active or placebo MJ. For each injection, measures of CV function and CNS PK [(15)O]water were made. Postsmoking, MJ influenced all measured CV and [(15)O]water PK parameters. C users reported significantly lower "highness" and smaller heart rate (HR) changes, which resulted in reduced rate pressure product (RPP) changes compared to O users, even though Delta(9)-tetrahydrocannabinol levels were higher, whereas changes in blood pressure (BP), arrival time, and [(15)O]water concentration were not significantly different between the groups. Significant CV changes resulted in changes in the whole-body distribution of cardiac output rather than changes in cerebral blood flow. Chronic MJ use produces tolerance to the HR increases induced by acute MJ smoking compared to changes observed in occasional users, without changing the effects on BP and [(15)O]water PK.
- Subjects :
- Adult
Blood Pressure drug effects
Dronabinol blood
Drug Interactions
Drug Tolerance
Female
Heart Rate drug effects
Humans
Male
Oxygen Radioisotopes
Tomography, Emission-Computed
Cardiovascular System drug effects
Central Nervous System metabolism
Marijuana Smoking adverse effects
Water metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0091-2700
- Volume :
- 44
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 15199080
- Full Text :
- https://doi.org/10.1177/0091270004265699