Interleukin-1beta system in anorectic catabolic tumor-bearing rats.

Authors :: Turrin NP
Ilyin SE
Gayle DA
Plata-Salamán CR
Ramos EJ
Laviano A
Das UN
Inui A
Meguid MM
Source :: Current opinion in clinical nutrition and metabolic care [Curr Opin Clin Nutr Metab Care] 2004 Jul; Vol. 7 (4), pp. 419-26.
Publication Year :: 2004
Abstract: Purpose of Review: The onset of cancer anorexia and the accompanying neurological symptoms and signs involve the general influence of cytokines on the brain. Using methylcholanthrene to induce tumors in Fischer 344 rats, we measured various specific components of the cytokine-induced anorectic reaction, including: (1) IL-1beta system components (ligand, signaling receptor, receptor accessory proteins, and receptor antagonist); (2) TNF-alpha; (3) TGF-beta1; and (4) IFN-gamma in the tumor tissue, the liver and the brain.<br />Recent Findings: The data show that IL-1beta, TNF-alpha and IFN-gamma messenger RNA were detected in the tumor tissue of anorectic tumor-bearing rats. In brain regions, anorexia is associated with the upregulation of IL-1beta and its receptor mRNA. All other mRNA remained unchanged in the brain regions examined.<br />Summary: This suggests that IL-1beta and its receptor may play a significant role in this model of cancer-associated anorexia. In vivo, the characterization of cytokine components in the brain may provide data for potential pharmacological interventions to ameliorate the anorexia of disease.