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[Sex differences in coronary atherosclerosis: coronary angiography and intravascular ultrasonography].

Authors :
Hara H
Yajima J
Kirigaya H
Nagashima K
Oikawa Y
Sahara M
Nakatsu Y
Aizawa T
Source :
Journal of cardiology [J Cardiol] 2004 May; Vol. 43 (5), pp. 215-21.
Publication Year :
2004

Abstract

Objectives: Women have higher mortality and frequency of complications compared with men after coronary intervention. Possible differences in coronary atherosclerosis between men and women were investigated.<br />Methods: The left anterior descending arteries of 214 patients (164 men, mean age 62.3 +/- 9.10 years; 50 women, mean age 67.8 +/- 7.76 years) were examined. Lesion length, reference diameter, percentage diameter stenosis and minimal lumen diameter were measured by quantitative coronary angiography. Vessel area, lumen area, percentage area stenosis, and remodeling index were measured by intravascular ultrasonography, and presence of calcification in the lesion was classified. These parameters were compared between men and women.<br />Results: There were no significant differences in quantitative coronary angiography, but intravascular ultrasonography showed calcification was more severe in women, vessel area was significantly smaller in women (13.25 +/- 4.21 vs 15.91 +/- 4.35 mm2, p = 0.004), and remodeling index was significantly lower in women (0.95 +/- 0.13 vs 1.04 +/- 0.18, p = 0.015).<br />Conclusions: Vessel area measured by intravascular ultrasonography was significantly smaller in women, and calcification was more severe in women. Such factors may be involved in the higher mortality in women.

Details

Language :
Japanese
ISSN :
0914-5087
Volume :
43
Issue :
5
Database :
MEDLINE
Journal :
Journal of cardiology
Publication Type :
Academic Journal
Accession number :
15188608