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[Properties of the isolated Bacillus subtilis strains and their influence on the intestinal microflora of experimental mice].
- Source :
-
Zhurnal mikrobiologii, epidemiologii i immunobiologii [Zh Mikrobiol Epidemiol Immunobiol] 2004 Mar-Apr (2), pp. 91-4. - Publication Year :
- 2004
-
Abstract
- The cultural, physiologo-biochemical adhesive and antagonistic properties of B. subtilis strains with good prospects for use as biotherapeutic preparations were studied. For further studies B. subtilis strain No. 1719 was chosen. In experiments on non-inbred white mice the animals were treated by the preparation Cifran used for their selective decontamination from opportunistic microflora and for the creation of the state of dysbiosis. The influence of the spore-forming microbe on the parietal microflora of the large intestine of the animals was shown. Reliable data on the changes in the number of microorganisms (CFU/ml) per 1 cm of the surface of the large intestine were established. As markers making it possible to evaluate the action of biotherapeutic and other medicinal remedies, easily determinable ratios of lac+/lac- of bacteria and Staphylococcus aureus/Staphylococcus spp. was proposed.
- Subjects :
- Animals
Antibiosis
Bacillus subtilis isolation & purification
Bacteria genetics
Bacteria isolation & purification
Bacterial Adhesion
Ciprofloxacin analogs & derivatives
Colony Count, Microbial
Disease Models, Animal
Drug Evaluation, Preclinical
Humans
Intestinal Diseases chemically induced
Intestinal Diseases microbiology
Lac Operon
Mice
Staphylococcaceae isolation & purification
Bacillus subtilis physiology
Fluoroquinolones
Intestinal Diseases therapy
Intestine, Large microbiology
Probiotics therapeutic use
Subjects
Details
- Language :
- Russian
- ISSN :
- 0372-9311
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Zhurnal mikrobiologii, epidemiologii i immunobiologii
- Publication Type :
- Academic Journal
- Accession number :
- 15188573