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Helicobacter pylori and malignant lymphoma in Spain.
- Source :
-
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2004 Jun; Vol. 13 (6), pp. 944-8. - Publication Year :
- 2004
-
Abstract
- Unlabelled: Helicobacter pylori has been associated with gastric adenocarcinoma and gastric lymphoma. We report on the systematic evaluation of serologic detection of H. pylori in a lymphoma case-control study.<br />Methods: Cases (N = 536) were consecutive patients newly diagnosed with a lymphoid malignancy between 1998 and 2002 in four centers in Spain. Lymphomas were diagnosed and classified using the WHO Classification. Controls (N = 603) were hospitalized patients frequency-matched to the cases by 5-year age group, sex, and study center. Severe immunocompromised patients were excluded as controls. Patients underwent a personal interview and blood sampling. H. pylori infection was evaluated by the presence of IgG antibodies using the Premier enzyme immunoassay kit (Meridian Diagnostics Inc., Cincinnati, OH). Logistic regression analysis was used to estimate the odds ratios and 95% confidence intervals (OR, 95% CI) for lymphoma categories.<br />Results: Anti-H. pylori antibodies were detected in 68.5% of the cases and 71.3% of the controls (P = 0.29) H. pylori was associated with a 3-fold excess risk of splenic marginal B-cell lymphoma (OR = 3.97, 95% CI = 0.92-17.16). H. pylori was not associated with an overall increased risk of extranodal lymphomas (OR = 0.73, 95% CI = 0.44-1.22) but when specific sites were explored, the four mucosa-associated lymphoid tissue and the six diffuse large B-cell lymphomas primary localized in the stomach were all H. pylori seropositive.<br />Conclusion: Persistent infection with H. pylori may be implicated in the development of lymphomas of the gastric mucosa and of the spleen. These results could have clinical implications in the management of splenic marginal zone lymphomas.
- Subjects :
- Adult
Aged
Case-Control Studies
Female
Helicobacter Infections blood
Helicobacter Infections complications
Helicobacter Infections epidemiology
Helicobacter pylori isolation & purification
Humans
Immunoglobulin G blood
Interviews as Topic
Logistic Models
Lymphoma, B-Cell diagnosis
Male
Middle Aged
Risk Factors
Seroepidemiologic Studies
Spain epidemiology
Stomach Neoplasms diagnosis
Antibodies, Bacterial blood
Helicobacter pylori immunology
Lymphoma, B-Cell microbiology
Stomach Neoplasms microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1055-9965
- Volume :
- 13
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 15184250