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Genotoxic effectivity--comparison of 36 nitrated furan and arenofuran derivatives on a quantitative scale. Statistical comparison of T7 and other short-term tests.
- Source :
-
Mutagenesis [Mutagenesis] 1992 Jul; Vol. 7 (4), pp. 243-9. - Publication Year :
- 1992
-
Abstract
- Thirty-six nitrated furan and arenofuran derivatives were measured and quantitatively characterized by the T7 inactivation test. A wide range of substances previously studied allowed us to compare the collected quantitative data with those obtained by other workers using different short-term tests. Based on comparative statistical evaluation of these data a borderline was determined for the genotoxic effect: compounds having in our short-term test mutagenicity index (MI) values smaller than 8.0 are positive while the higher values represent negative genotoxicity. Classification of 36 nitrofuran/nitroarenofuran derivatives is given both on the basis of the quantitative genotoxicity scale and in terms of +/- on the qualitative scale. All but one compound were found to be genotoxic and the genotoxic activities of these compounds were compared with the results of other carcinogenicity or mutagenicity tests.
- Subjects :
- Carcinogenicity Tests
Molecular Structure
Mutagenicity Tests methods
Mutation genetics
Nitrates
Nitrofurans toxicity
Reference Standards
Salmonella typhimurium genetics
T-Phages genetics
Time Factors
Transformation, Genetic genetics
Chromosome Aberrations genetics
Furans toxicity
Mutagens toxicity
T-Phages drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0267-8357
- Volume :
- 7
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Mutagenesis
- Publication Type :
- Academic Journal
- Accession number :
- 1518407
- Full Text :
- https://doi.org/10.1093/mutage/7.4.243