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Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response.

Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response.

Authors :
Liliensiek B
Weigand MA
Bierhaus A
Nicklas W
Kasper M
Hofer S
Plachky J
Gröne HJ
Kurschus FC
Schmidt AM
Yan SD
Martin E
Schleicher E
Stern DM
Hämmerling G Gü
Nawroth PP
Arnold B
Source :
The Journal of clinical investigation [J Clin Invest] 2004 Jun; Vol. 113 (11), pp. 1641-50.
Publication Year :
2004

Abstract

While the initiation of the adaptive and innate immune response is well understood, less is known about cellular mechanisms propagating inflammation. The receptor for advanced glycation end products (RAGE), a transmembrane receptor of the immunoglobulin superfamily, leads to perpetuated cell activation. Using novel animal models with defective or tissue-specific RAGE expression, we show that in these animal models RAGE does not play a role in the adaptive immune response. However, deletion of RAGE provides protection from the lethal effects of septic shock caused by cecal ligation and puncture. Such protection is reversed by reconstitution of RAGE in endothelial and hematopoietic cells. These results indicate that the innate immune response is controlled by pattern-recognition receptors not only at the initiating steps but also at the phase of perpetuation.

Details

Language :
English
ISSN :
0021-9738
Volume :
113
Issue :
11
Database :
MEDLINE
Journal :
The Journal of clinical investigation
Publication Type :
Academic Journal
Accession number :
15173891
Full Text :
https://doi.org/10.1172/JCI18704