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[Pharmacological effects of Daphne genkwa and Chinese medical prescription, "Jyu-So-To"].
- Source :
-
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan [Yakugaku Zasshi] 2004 Jun; Vol. 124 (6), pp. 349-54. - Publication Year :
- 2004
-
Abstract
- Daphne genkwa (Thymelaeaceae) has been used as a folk medicine in China. We investigated the effects of D. genkwa and Jyu-So-To on various pharmacologic models in mice including the azoxymethane (AOM)-induced colonic aberrant crypt focus formation assay, ornithine decarboxylase (ODC) activity assay, and two types of mouse ear swelling model. Administration of 236.3 ppm of Jyu-So-To in drinking water significantly suppressed AOM-induced colonic aberrant crypt focus formation (p < 0.05), with an inhibitory ratio of 46.7%. The effects of several extracts with organic solvents of D. genkwa on murine epidermal ODC activity were examined. In particular, the inhibitory ratio of the n-hexane extract was 30.8%. In the 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced ear edema model in mice, the methanol extract resulted in 56.3% inhibition compared with the control. On the other hand, there are two peaks of responses at 1 h (immediate-phase reaction; IPR) and 24 h (late-phase reaction) in biphasic cutaneous reactions, which are enhanced in the dinitrofluorobenzene model (DNFB). The water extract of D. genkwa clearly inhibited the IPR ear swelling. These results suggest that D. genkwa and Jyu-So-To should be a promising source of antitumor, antiinflammatory, and antiallergy agents.
- Subjects :
- Animals
Anti-Allergic Agents
Anti-Inflammatory Agents
Antineoplastic Agents, Phytogenic
Azoxymethane
Colonic Neoplasms chemically induced
Dinitrofluorobenzene
Ear Diseases chemically induced
Edema chemically induced
Female
Hypersensitivity etiology
Male
Mice
Mice, Inbred Strains
Ornithine Decarboxylase metabolism
Tetradecanoylphorbol Acetate
Colonic Neoplasms prevention & control
Daphne
Drugs, Chinese Herbal pharmacology
Drugs, Chinese Herbal therapeutic use
Ear Diseases prevention & control
Edema prevention & control
Hypersensitivity prevention & control
Phytotherapy
Plant Extracts pharmacology
Plant Extracts therapeutic use
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0031-6903
- Volume :
- 124
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
- Publication Type :
- Academic Journal
- Accession number :
- 15170070
- Full Text :
- https://doi.org/10.1248/yakushi.124.349