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The DNA polymerases of Leishmania mexicana.
- Source :
-
FEMS microbiology letters [FEMS Microbiol Lett] 1992 Aug 01; Vol. 74 (1), pp. 71-5. - Publication Year :
- 1992
-
Abstract
- Two previously isolated DNA polymerases from the parasitic protozoan Leishmania mexicana were further characterized by exposure to inhibitors of mammalian DNA polymerases. DNA polymerase A, a high molecular mass enzyme, and DNA polymerase B, a beta-like DNA polymerase were compared to each other and to their mammalian counterparts regarding pH optimum, utilization of templates, and response to various inhibitors and ionic strengths. The results suggest that the DNA polymerases from L. mexicana differ from the host enzymes and may offer a target for chemotherapeutic intervention.
- Subjects :
- Animals
DNA Polymerase I antagonists & inhibitors
DNA Polymerase I isolation & purification
DNA Polymerase III antagonists & inhibitors
DNA Polymerase III isolation & purification
Hydrogen-Ion Concentration
Molecular Weight
Potassium Chloride pharmacology
Sodium Chloride pharmacology
Templates, Genetic
DNA Polymerase I metabolism
DNA Polymerase III metabolism
Leishmania mexicana enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 0378-1097
- Volume :
- 74
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- FEMS microbiology letters
- Publication Type :
- Academic Journal
- Accession number :
- 1516809
- Full Text :
- https://doi.org/10.1016/0378-1097(92)90738-a