Muscle blood flow in diabetes mellitus. Evidence of abnormality after exercise.

Authors :: Menon RK
Grace AA
Burgoyne W
Fonseca VA
James IM
Dandona P
Source :: Diabetes care [Diabetes Care] 1992 May; Vol. 15 (5), pp. 693-5.
Publication Year :: 1992
Abstract: Objective: To determine whether muscle blood flow before and after exercise is abnormal in patients with diabetes mellitus.<br />Research Design and Methods: Muscle blood flow (MBF) was measured with the 133Xe clearance technique in 15 nondiabetic subjects, 10 patients with insulin-dependent diabetes mellitus (IDDM), and 11 patients with non-insulin-dependent diabetes (NIDDM) at rest and after exercise. None of the patients had neuropathy.<br />Results: The median resting MBF was similar in all three groups. The median postexercise MBF was significantly greater in nondiabetic subjects (40.1 ml.min-1.100 g-1 of tissue) than in patients with IDDM (25.7 ml.min-1.100 g-1 of tissue; P less than 0.01) or NIDDM (14 ml.min-1.100 g-1 of tissue; P less than 0.01). The difference between IDDM and NIDDM was not significant.<br />Conclusions: Diabetic patients have abnormalities of MBF in response to exercise. This abnormality occurs in the absence of clinical diabetic neuropathy.