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Recognition of HLA-A3 and HLA-A11 by KIR3DL2 is peptide-specific.
- Source :
-
European journal of immunology [Eur J Immunol] 2004 Jun; Vol. 34 (6), pp. 1673-9. - Publication Year :
- 2004
-
Abstract
- The recognition of MHC class I molecules by killer cell immunoglobulin-like receptors (KIR) is central to the control of NK cell function and can also modulate the CTL activation threshold. Among KIR receptors, KIR3DL2 is thought to interact with HLA-A3 and -A11, although direct evidence has been lacking. In this study, we show that HLA-A3 and -A11 tetramers specifically bind to KIR3DL2*001 transfectants and that this recognition is peptide-specific. Single amino acid substitutions in the nonamer peptide underline a critical role for residue 8 in recognition of KIR3DL2. However, the role of this interaction in vivo still remains to be established.
Details
- Language :
- English
- ISSN :
- 0014-2980
- Volume :
- 34
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- European journal of immunology
- Publication Type :
- Academic Journal
- Accession number :
- 15162437
- Full Text :
- https://doi.org/10.1002/eji.200425089