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Role of HtrA in the virulence and competence of Streptococcus pneumoniae.
- Source :
-
Infection and immunity [Infect Immun] 2004 Jun; Vol. 72 (6), pp. 3584-91. - Publication Year :
- 2004
-
Abstract
- HtrA is a major virulence factor of Streptococcus pneumoniae (the pneumococcus). Deletion of the gene for HtrA from strain D39 of the pneumococcus completely abolished its virulence in mouse models of pneumonia and bacteremia, while the virulence of a second strain (TIGR4) was dramatically reduced. HtrA-negative mutants induced much less inflammation in the lungs during pneumonia than the wild type. HtrA is involved in the ability of the pneumococcus to grow at high temperatures, to resist oxidative stress, and to undergo genetic transformation. The expression and cellular location of several known virulence factors of the pneumococcus were not affected by the lack of HtrA.
- Subjects :
- Animals
Animals, Outbred Strains
Bacteremia mortality
Bacteremia physiopathology
Disease Models, Animal
Female
Heat-Shock Proteins genetics
Humans
Hydrogen Peroxide pharmacology
Mice
Mutation
Periplasmic Proteins genetics
Pneumonia, Pneumococcal mortality
Pneumonia, Pneumococcal physiopathology
Serine Endopeptidases genetics
Streptococcus pneumoniae genetics
Virulence
Bacteremia microbiology
Heat-Shock Proteins metabolism
Periplasmic Proteins metabolism
Pneumonia, Pneumococcal microbiology
Serine Endopeptidases metabolism
Streptococcus pneumoniae growth & development
Streptococcus pneumoniae pathogenicity
Subjects
Details
- Language :
- English
- ISSN :
- 0019-9567
- Volume :
- 72
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 15155668
- Full Text :
- https://doi.org/10.1128/IAI.72.6.3584-3591.2004