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CpG oligodeoxynucleotides improve the survival of pregnant and fetal mice following Listeria monocytogenes infection.
- Source :
-
Infection and immunity [Infect Immun] 2004 Jun; Vol. 72 (6), pp. 3543-8. - Publication Year :
- 2004
-
Abstract
- Listeria infection during pregnancy can cause the death of both mother and fetus. Previous studies established that immunostimulatory CpG oligodeoxynucleotides (ODN) increase the resistance of healthy adult mice to many infectious pathogens, including Listeria monocytogenes. This study examines whether the innate immune response elicited by CpG ODN can reduce the susceptibility of pregnant mice to lethal listeria challenge. The results indicate that CpG ODN treatment significantly improves maternal survival and reduces pathogen transmission to offspring. CpG ODN administered during pregnancy did not induce abortion, birth defects, or reduce the size or health of litters. These findings suggest that CpG ODN may provide a safe and effective means of improving the health of mothers and fetuses during pregnancy.
- Subjects :
- Animals
Female
Immunity, Innate
Infectious Disease Transmission, Vertical prevention & control
Listeriosis drug therapy
Listeriosis microbiology
Mice
Mice, Inbred BALB C
Oligodeoxyribonucleotides immunology
Pregnancy
Pregnancy Complications, Infectious drug therapy
Pregnancy Complications, Infectious microbiology
Adjuvants, Immunologic administration & dosage
CpG Islands immunology
Listeria monocytogenes pathogenicity
Listeriosis mortality
Oligodeoxyribonucleotides administration & dosage
Pregnancy Complications, Infectious mortality
Subjects
Details
- Language :
- English
- ISSN :
- 0019-9567
- Volume :
- 72
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 15155663
- Full Text :
- https://doi.org/10.1128/IAI.72.6.3543-3548.2004