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The regulation of rhinovirus infection in vitro by IL-8, HuIFN-alpha, and TNF-alpha.
- Source :
-
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica [APMIS] 2004 Mar; Vol. 112 (3), pp. 172-82. - Publication Year :
- 2004
-
Abstract
- The influence of three important cytokines (IL-8, TNF-alpha, and HuIFN-alpha) on ongoing rhinovirus infections has been examined in vitro, individually or as combinations. TNF-alpha was able to transform traces of HRV infections into full-blown infections. Furthermore, TNF-alpha was able to down-regulate the antiviral action of HuIFN-alpha completely, even at levels of just a few pg/ml. This suggests that the induction of TNF-alpha by HRV may be part of the virus's strategy to minimize the interferon response which is part of the host's immune defence system. However, troxerutin (a flavonoid) was able to neutralize the downregulatory action of TNF-alpha on the HuIFN-alpha system at low levels and re-establish the antiviral activity ascribed to IFN-alpha. IL-8 exerted a minor influence on the interferon system, and had no influence on rhinovirus infections. The in vitro findings are supported, in part, by recent in vivo findings in a common cold pilot study.
- Subjects :
- Cell Line
Common Cold drug therapy
Common Cold immunology
Humans
Hydroxyethylrutoside analogs & derivatives
Hydroxyethylrutoside pharmacology
Rhinovirus physiology
Virus Replication drug effects
Interferon-alpha pharmacology
Interleukin-8 pharmacology
Rhinovirus drug effects
Tumor Necrosis Factor-alpha pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0903-4641
- Volume :
- 112
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
- Publication Type :
- Academic Journal
- Accession number :
- 15153159
- Full Text :
- https://doi.org/10.1111/j.1600-0463.2004.apm1120303.x