[The effects of Zheng's plant-protein on the proliferation of lymphocytes from patients with breast cancer and precancer].

Aim: To study the effect of Zheng's plant-protein(ZPP) and phytohemagglutinin(PHA) on proliferation of peripheral blood lymphocytes (PBL) and it's application value on the early diagnosis and therapy of breast cancer.
Methods: The proliferation assay was used (3)H-TdR incorporation test. The phenotypes of PBL were analysised by flow cytometry(FCM).
Results: The ZPP significantly and selectively enhanced proliferation activity of PBL of primary breast and precancer cases. Their stimulation indexes(SI) were 3.00+/-1.45 and 2.53+/-0.80, while the SI of simple hyperplasia cases and normal subjecties were 1.18+/-0.47 and 1.06+/-0.91. The former were significantly higher than the latter (P<0.01). The ZPP was also enhanced the expression level of CD3(+),CD4(+) and CD8(+) of PBL.
Conclusion: This results suggest that ZPP might be a beast cancer common antigen. These activity might be used in clinical implication to diagnosis and treatment of breast cancer.