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Intra-abdominal infections: review of the bacteriology, antimicrobial susceptibility and the role of ertapenem in their therapy.
- Source :
-
The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2004 Jun; Vol. 53 Suppl 2, pp. ii29-36. - Publication Year :
- 2004
-
Abstract
- Complicated intra-abdominal infections require a combination of surgery/drainage and antimicrobial therapy that is active against both the aerobic and the anaerobic bacteria that comprise the intestinal flora. Ertapenem, a parenteral carbapenem, is highly resistant to a wide variety of beta-lactamase enzymes, and has a broad spectrum of activity against bacteria associated with community-acquired infections including those of complicated intra-abdominal conditions. This article reviews the bacteriology of complicated intra-abdominal infections, their antimicrobial susceptibility, especially to anaerobes, the utility of animal models in these mixed infections, and the supportive clinical trials and in vitro susceptibility data that show ertapenem to be generally well tolerated and as effective as either piperacillin-tazobactam or ceftriaxone plus metronidazole in the therapy of complicated intra-abdominal infections.
- Subjects :
- Abdominal Abscess microbiology
Adolescent
Adult
Aged
Aged, 80 and over
Animals
Bacterial Infections microbiology
Clinical Trials as Topic
Community-Acquired Infections drug therapy
Community-Acquired Infections microbiology
Ertapenem
Female
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Rats
beta-Lactams
Abdomen
Abdominal Abscess drug therapy
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents therapeutic use
Bacteria, Anaerobic drug effects
Bacterial Infections drug therapy
Lactams pharmacology
Lactams therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0305-7453
- Volume :
- 53 Suppl 2
- Database :
- MEDLINE
- Journal :
- The Journal of antimicrobial chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 15150181
- Full Text :
- https://doi.org/10.1093/jac/dkh201