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Detection of occult tumor using indium 111-labeled anticarcinoembryonic antigen antibodies.
- Source :
-
Archives of surgery (Chicago, Ill. : 1960) [Arch Surg] 1992 Sep; Vol. 127 (9), pp. 1094-100. - Publication Year :
- 1992
-
Abstract
- Even with the advancement of radiologic techniques, metastatic cancers can still be difficult to detect. In this study, 48 patients suspected of having occult metastases were studied by radioimmunodetection following the administration of 92.5 to 181.3 MBq of indium 111-labeled monoclonal anticarcinoembryonic antigen antibody. All but seven patients were thought to have metastatic colorectal carcinoma. In the majority of cases, physical examinations and computed tomographic scans had failed to detect a lesion. At least one lesion that was later proved to exist was detected in 34 of the 50 studies performed on these patients. Seven of eight patients with normal radioimmunodetection scans remain free of disease. One hundred one sites were detected overall; 60 were considered true-positive sites and 27 false-positive sites. Fourteen sites remained in question. Nineteen false-negative sites occurred. Radioimmunoimaging appears valuable for the detection of occult cancer where standard, noninterventional techniques have failed to detect the suspected disease.
- Subjects :
- Carcinoembryonic Antigen analysis
False Positive Reactions
Female
Humans
Immunoglobulin Fab Fragments
Immunoglobulin G
Male
Sensitivity and Specificity
Tomography, Emission-Computed, Single-Photon
Carcinoembryonic Antigen immunology
Indium Radioisotopes
Neoplasm Metastasis diagnostic imaging
Radioimmunodetection
Subjects
Details
- Language :
- English
- ISSN :
- 0004-0010
- Volume :
- 127
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Archives of surgery (Chicago, Ill. : 1960)
- Publication Type :
- Academic Journal
- Accession number :
- 1514913
- Full Text :
- https://doi.org/10.1001/archsurg.1992.01420090102015