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Prognostic value of thyroglobulin serum levels and 131I whole-body scan after initial treatment of low-risk differentiated thyroid cancer.
- Source :
-
Thyroid : official journal of the American Thyroid Association [Thyroid] 2004 Apr; Vol. 14 (4), pp. 301-6. - Publication Year :
- 2004
-
Abstract
- Diagnostic iodine-131 whole-body scan ((131)I-WBS) and serum thyroglobulin values (Tg) performed 6 to 12 months after thyroid ablation for differentiated thyroid carcinoma were evaluated in 194 consecutive patients at the Hospital de Navarra, (Pamplona, Spain). All patients underwent near-total thyroidectomy and (131)I ablation with 3.7 GBq. Patients with positive anti-Tg antibodies or with (131)I uptake outside the neck were previously excluded. Uptake of (131)I in the thyroid bed was detected in 27 patients (13.9%). Serum Tg levels were below 0.5 ng/mL in 133 patients, ranged from 0.5-10 ng/mL in 39 patients, and was above 10 ng/mL in 22 patients. After a follow-up of 7.7 +/- 3.3 years, persistence of the illness has been observed in 2 patients with undetectable Tg (1.5%), but metastases were not detected in any case. In those with Tg higher than 0.5 ng/mL, 29 of 61 patients had persistence of the disease (47.5%) with evidence of metastases in 15 (24.5%), irrespective of the initial total body scan (131)I uptake. In conclusion, serum Tg levels obtained after thyroid ablation has a good prognostic value and permits the selection of patients for further diagnostic studies, while diagnostic (131)I-WBS performed at that time did not correlate with results of Tg and scarcely provides additional information.
- Subjects :
- Biomarkers blood
Female
Follow-Up Studies
Humans
Male
Neoplasm Staging
Prognosis
Radionuclide Imaging
Retrospective Studies
Thyroid Neoplasms blood
Thyroid Neoplasms mortality
Thyroid Neoplasms pathology
Time Factors
Iodine Radioisotopes pharmacokinetics
Thyroglobulin blood
Thyroid Neoplasms diagnostic imaging
Thyroid Neoplasms surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1050-7256
- Volume :
- 14
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Thyroid : official journal of the American Thyroid Association
- Publication Type :
- Academic Journal
- Accession number :
- 15142364
- Full Text :
- https://doi.org/10.1089/105072504323030960