[Implication of basic biomedical studies for phthisiology].

The paper presents the data of basic studies in the field of phthisiology at the molecular genetic levels, which explain the mechanisms of the drug resistance and intracellular persistence of M. tuberculosis. The results of deciphering the genome of M. tuberculosis and those of conducted studies have allowed the authors to substantiate the prospects of gene therapy of tuberculosis and its diagnosis by using the proteins CFP and ESAT, as well as new approaches to vaccine prevention.