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Aryloxy phosphoramidate triesters as pro-tides.
- Source :
-
Mini reviews in medicinal chemistry [Mini Rev Med Chem] 2004 May; Vol. 4 (4), pp. 371-81. - Publication Year :
- 2004
-
Abstract
- We herein describe the development of aryloxy phosphoramidate triesters as an effective pro-tide motif for the intracellular delivery of charged bio-active antiviral nucleoside monophosphates. The review covers the discovery of such aryl phosphoramidates, their mechanism of action and structure-activity relationships. The application of this strategy to a range of antiviral nucleosides is highlighted.
- Subjects :
- Amino Acids chemistry
Amino Acids metabolism
Amino Acids pharmacology
Antiviral Agents chemical synthesis
Antiviral Agents metabolism
Drug Design
Enzyme Activation drug effects
Esters metabolism
Esters pharmacology
Humans
Molecular Structure
Nucleosides chemistry
Nucleosides metabolism
Nucleosides pharmacology
Prodrugs metabolism
Prodrugs pharmacology
Sensitivity and Specificity
Structure-Activity Relationship
Amides chemistry
Antiviral Agents chemistry
Esters chemistry
Phosphoric Acids chemistry
Prodrugs chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1389-5575
- Volume :
- 4
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Mini reviews in medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 15134540
- Full Text :
- https://doi.org/10.2174/1389557043403936