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Orthologous gene-expression profiling in multi-species models: search for candidate genes.
- Source :
-
Genome biology [Genome Biol] 2004; Vol. 5 (5), pp. R34. Date of Electronic Publication: 2004 Apr 27. - Publication Year :
- 2004
-
Abstract
- Microarray-driven gene-expression profiles are generally produced and analyzed for a single specific experimental model. We have assessed an analytical approach that simultaneously evaluates multi-species experimental models within a particular biological condition using orthologous genes as linkers for the various Affymetrix microarray platforms on multi-species models of ventilator-associated lung injury. The results suggest that this approach may be a useful tool in the evaluation of biological processes of interest and selection of process-related candidate genes.
- Subjects :
- Animals
Cell Line
Disease Models, Animal
Dogs
Endothelium chemistry
Endothelium cytology
Endothelium metabolism
Gene Expression Profiling statistics & numerical data
Genes genetics
Humans
Lung chemistry
Lung metabolism
Lung Diseases genetics
Mice
Oligonucleotide Array Sequence Analysis statistics & numerical data
Rats
Species Specificity
Gene Expression Profiling methods
Models, Genetic
Oligonucleotide Array Sequence Analysis methods
Subjects
Details
- Language :
- English
- ISSN :
- 1474-760X
- Volume :
- 5
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Genome biology
- Publication Type :
- Academic Journal
- Accession number :
- 15128448
- Full Text :
- https://doi.org/10.1186/gb-2004-5-5-r34