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Quality of life improvement with conversion to lamotrigine monotherapy.
- Source :
-
Epilepsy & behavior : E&B [Epilepsy Behav] 2004 Apr; Vol. 5 (2), pp. 224-30. - Publication Year :
- 2004
-
Abstract
- This report describes the effect on patient-reported quality of life (QOL) after reduction from two drugs to monotherapy with lamotrigine. Patients taking lamotrigine (LTG) with an enzyme-inducing drug were converted to LTG monotherapy for a 12-week follow-up. Changes in QOLIE-31 between baseline and follow-up were compared with physicians' global change ratings and patient-reported health status. Total QOLIE-31 scores increased 10.7 points for patients rated by physicians as having mild improvement, and 17 points for those reported as having moderate to marked improvement. Subscale scores also increased by minimum important change (MIC) amounts (> or = 11.76), with the largest change in Cognition, Energy, Medication Effects, and Seizure Worry subscales. The data also support > or = 11 MIC as a clinically important change in total score for the QOLIE-31. Exploratory analyses also provide information about MIC for individual subscales (8-18 for physician rated global change, 10-26 for patient-rated global health status change). This study demonstrates the value of reduction to monotherapy from the patients' and physicians' perspectives.
- Subjects :
- Adolescent
Adult
Anticonvulsants adverse effects
Carbamazepine administration & dosage
Carbamazepine adverse effects
Drug Therapy, Combination
Electroencephalography drug effects
Epilepsies, Partial psychology
Female
Humans
Lamotrigine
Male
Middle Aged
Patient Satisfaction
Phenytoin administration & dosage
Phenytoin adverse effects
Substance Withdrawal Syndrome drug therapy
Substance Withdrawal Syndrome psychology
Triazines adverse effects
Anticonvulsants administration & dosage
Epilepsies, Partial drug therapy
Quality of Life psychology
Sick Role
Triazines administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1525-5050
- Volume :
- 5
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Epilepsy & behavior : E&B
- Publication Type :
- Academic Journal
- Accession number :
- 15123024
- Full Text :
- https://doi.org/10.1016/j.yebeh.2003.11.031