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Nodal signaling: CrypticLefty mechanism of antagonism decoded.
- Source :
-
Current biology : CB [Curr Biol] 2004 May 04; Vol. 14 (9), pp. R341-3. - Publication Year :
- 2004
-
Abstract
- The secreted TGFbeta factor Lefty antagonizes Nodal signaling during vertebrate embryogenesis, but how it does so has been a mystery. Recent analyses have elucidated the molecular mechanisms underlying this function of Lefty.
- Subjects :
- Animals
Epidermal Growth Factor metabolism
Glycoproteins metabolism
Left-Right Determination Factors
Nodal Protein
Transforming Growth Factor beta physiology
Signal Transduction physiology
Transforming Growth Factor beta antagonists & inhibitors
Transforming Growth Factor beta metabolism
Vertebrates embryology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-9822
- Volume :
- 14
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Current biology : CB
- Publication Type :
- Academic Journal
- Accession number :
- 15120085
- Full Text :
- https://doi.org/10.1016/j.cub.2004.04.020