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Synthesis of benzo-fused lactams and lactones via Ru(II)-catalyzed cycloaddition of amide- and ester-tethered alpha,omega-diynes with terminal alkynes: electronic directing effect of internal conjugated carbonyl group.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2004 May 07; Vol. 2 (9), pp. 1287-94. Date of Electronic Publication: 2004 Apr 07. - Publication Year :
- 2004
-
Abstract
- In the presence of a catalytic amount of Cp*RuCl(cod), 1,6- and 1,7-diynes connected by an amide or an ester tether underwent cycloaddition with terminal alkynes at room temperature to give rise to cycloadducts in 40-93% yields with 63 : 37-83 : 17 regioisomer ratios.
Details
- Language :
- English
- ISSN :
- 1477-0520
- Volume :
- 2
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 15105918
- Full Text :
- https://doi.org/10.1039/b402649g