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Selenoprotein P protects low-density lipoprotein against oxidation.
- Source :
-
Free radical research [Free Radic Res] 2004 Feb; Vol. 38 (2), pp. 123-8. - Publication Year :
- 2004
-
Abstract
- Selenoprotein P (SeP) is an extracellular glycoprotein with 8-10 selenocysteines per molecule, containing approximately 50% of total selenium in human serum. An antioxidant function of SeP has been postulated. In the present study, we show that SeP protects low-density lipoproteins (LDL) against oxidation in a cell-free in-vitro system. LDL were isolated from human blood plasma and oxidized with CuCl2, 2,2'-azobis(2-amidinopropane) (AAPH) or peroxynitrite in the presence or absence of SeP, using the formation of conjugated dienes as parameter for lipid peroxidation. SeP delayed the CuCl2- and AAPH-induced LDL oxidation significantly and more efficiently than bovine serum albumin used as control. In contrast, SeP was not capable of inhibiting peroxynitrite-induced LDL oxidation. The protection of LDL against CuCl2- and AAPH-induced oxidation provides evidence for the antioxidant capacity of SeP. Because SeP associates with endothelial membranes, it may act in vivo as a protective factor inhibiting the oxidation of LDL by reactive oxygen species.
- Subjects :
- Amidines antagonists & inhibitors
Copper antagonists & inhibitors
Humans
Oxidation-Reduction
Peroxynitrous Acid antagonists & inhibitors
Proteins metabolism
RNA-Binding Proteins metabolism
Selenium metabolism
Selenocysteine metabolism
Selenoprotein P
Selenoproteins
Antioxidants pharmacology
Lipoproteins, LDL metabolism
Oxidants antagonists & inhibitors
Proteins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1071-5762
- Volume :
- 38
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Free radical research
- Publication Type :
- Academic Journal
- Accession number :
- 15104205
- Full Text :
- https://doi.org/10.1080/10715760320001634852