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[Antimicrobial susceptibilities of Streptococcus pneumoniae and Haemophilus influenzae isolated from children with meningitis].
- Source :
-
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases [Kansenshogaku Zasshi] 2004 Jan; Vol. 78 (1), pp. 40-5. - Publication Year :
- 2004
-
Abstract
- Between April 2001 and March 2003, we studied minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of 7 strains of Streptococcus pneumoniae and 8 strains of Haemophilus influenzae isolated from children with meningitis. The age range of the patients was from 4 months to 5 years. Susceptibilities of ampicillin (ABPC), cefotaxime (CTX), panipenem (PAPM), and vancomycin (VCM) in S. pneumoniae and those of ABPC, CTX, ceftriaxone (CTRX), and meropenem (MEPM) in H. influenzae were measured. MICs of ABPC, CTX, PAPM, and VCM to S. pneumoniae were < or = 0.06-2, < or = 0.06-0.5, < or = 0.06, and 0.25-0.5 microgram/ml and MICs of ABPC, CTX, CTRX, and MEPM to H. influenzae were 0.12-64, < or = 0.06-0.5, < or = 0.06-0.12, and < or = 0.06-0.25 microgram/ml, respectively. In 5 of all strains, difference between MIC and MBC to ABPC was observed. Four strains out of them had mutations of penicillin binding protein genes measured by PCR methods.
- Subjects :
- Ampicillin pharmacology
Cefotaxime pharmacology
Ceftriaxone pharmacology
Child, Preschool
Drug Resistance, Bacterial
Humans
Infant
Meropenem
Thienamycins pharmacology
Vancomycin pharmacology
Haemophilus influenzae drug effects
Haemophilus influenzae isolation & purification
Meningitis microbiology
Streptococcus pneumoniae drug effects
Streptococcus pneumoniae isolation & purification
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0387-5911
- Volume :
- 78
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 15103892
- Full Text :
- https://doi.org/10.11150/kansenshogakuzasshi1970.78.40