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Responses of small intestinal architecture and function over time to environmental factors in a tropical population.
- Source :
-
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2004 Apr; Vol. 70 (4), pp. 412-9. - Publication Year :
- 2004
-
Abstract
- To determine the response of the small intestinal mucosa to environmental conditions, we studied changes in mucosal architecture and function in a longitudinal cohort study in African adults. Over three consecutive years, 238 adults submitted monthly stool samples for parasitologic and bacteriologic analysis and underwent an annual endoscopic jejunal biopsy for mucosal morphometry. Absorption and permeability assays were performed on the same day as the enteroscopy. Variation in mucosal architecture and function was correlated with environmental factors and stool microbiology. The whole cohort had structural and functional evidence of tropical enteropathy, but structure and function were only weakly correlated. There were marked changes over time, and seasonal variation was observed in villous height (16%), xylose recovery (16%), and permeability (28%). Asymptomatic intestinal infections were common. Enteropathy was more severe in participants with Citrobacter rodentium or hookworm ova in the stool sample taken one month before the investigations were performed.
- Subjects :
- Adult
Biopsy
Cohort Studies
Endoscopy, Gastrointestinal
Feces microbiology
Feces parasitology
Female
HIV Infections pathology
HIV-1 growth & development
Histocytochemistry
Humans
Intestinal Absorption physiology
Intestinal Mucosa microbiology
Intestinal Mucosa parasitology
Intestinal Mucosa ultrastructure
Intestine, Small microbiology
Intestine, Small parasitology
Intestine, Small ultrastructure
Logistic Models
Longitudinal Studies
Male
Seasons
Time Factors
Tropical Climate
Xylose metabolism
Zambia
Intestinal Mucosa physiology
Intestine, Small physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9637
- Volume :
- 70
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The American journal of tropical medicine and hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 15100456