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Circulating auto-antibody against hepatoma-derived growth factor (HDGF) in patients with ulcerative colitis.
- Source :
-
Hepato-gastroenterology [Hepatogastroenterology] 2004 Mar-Apr; Vol. 51 (56), pp. 470-5. - Publication Year :
- 2004
-
Abstract
- Background/aims: Various circulating auto-antibodies have been reported in patients with ulcerative colitis. Hepatoma-derived growth factor (HDGF) is a mitogen, localized dominantly in the nucleus of proliferating cells. In this study, we demonstrated the circulating anti-HDGF auto-antibody and investigated its clinical roles in patients with ulcerative colitis.<br />Methodology: Anti-HDGF IgG antibodies were measured by the enzyme-linked immunosorbent assay with recombinant HDGF in 20 healthy volunteers and 40 patients with ulcerative colitis.<br />Results: Circulating anti-HDGF antibody was detected in the serum of a patient with total colitis by Western blotting. Anti-HDGF auto-antibodies were detected at 65.6% in the serum of patients with total/left-sided colitis, compared with healthy subjects at 10%. During active stage, the circulating anti-HDGF auto-antibodies were detected at a higher frequency of 78.3% than those in remission stage at 37.5%. Furthermore, the titers during active colitis were higher than those during the remission stage. Anti-HDGF auto-antibodies were not detected in any patients with proctitis.<br />Conclusions: These findings suggest that anti-HDGF auto-antibodies in the serum of patients with ulcerative colitis would help to classify the total/left-sided colitis from proctitis, and the serial measurement of the titer would also be a good marker for the active colitis.
- Subjects :
- Blotting, Western
Colitis, Ulcerative metabolism
Enzyme-Linked Immunosorbent Assay
Humans
Intercellular Signaling Peptides and Proteins metabolism
Intestinal Mucosa metabolism
Proctitis immunology
Autoantibodies blood
Colitis, Ulcerative immunology
Intercellular Signaling Peptides and Proteins immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0172-6390
- Volume :
- 51
- Issue :
- 56
- Database :
- MEDLINE
- Journal :
- Hepato-gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 15086185