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Spontaneous retinal activity modulates BDNF trafficking in the developing chick visual system.
- Source :
-
Molecular and cellular neurosciences [Mol Cell Neurosci] 2004 Apr; Vol. 25 (4), pp. 549-57. - Publication Year :
- 2004
-
Abstract
- Both neuronal activity and neurotrophin signaling play critical roles in normal CNS development. This study examined whether spontaneous retinal activity (SRA) also governs the axonal transport of endogenous brain-derived neurotrophic factor (BDNF) protein within the developing chick visual system. In previous work, we have found that during the normal period of SRA, retinal BDNF protein levels decrease by about 50% while BDNF mRNA levels remain elevated. Here, we show that the blockade of SRA with tetrodotoxin (TTX), or the blockade of axonal transport with colchicine, both reversed the normal mismatch between retinal BDNF mRNA and protein. The axonal transport of retinal-derived BDNF in segments of the optic nerve as well as tectal-derived BDNF protein transported in segments of the optic tract were both significantly reduced after very brief periods of activity blockade. These results suggest that normal SRA plays a role in regulating the axonal transport of endogenous BDNF protein.
- Subjects :
- Action Potentials physiology
Animals
Axonal Transport drug effects
Brain-Derived Neurotrophic Factor genetics
Cell Differentiation drug effects
Cell Differentiation physiology
Chick Embryo
Colchicine pharmacology
Optic Nerve embryology
Optic Nerve metabolism
Protein Transport drug effects
Protein Transport physiology
RNA, Messenger metabolism
Retina cytology
Retina embryology
Retinal Ganglion Cells cytology
Retinal Ganglion Cells metabolism
Sodium Channel Blockers pharmacology
Superior Colliculi embryology
Synaptic Transmission physiology
Tetrodotoxin pharmacology
Visual Pathways embryology
Axonal Transport physiology
Brain-Derived Neurotrophic Factor metabolism
Retina physiology
Superior Colliculi metabolism
Visual Pathways metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1044-7431
- Volume :
- 25
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Molecular and cellular neurosciences
- Publication Type :
- Academic Journal
- Accession number :
- 15080885
- Full Text :
- https://doi.org/10.1016/j.mcn.2003.11.009