Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display library.

Authors :: Karle S
Planque S
Nishiyama Y
Taguchi H
Zhou YX
Salas M
Lake D
Thiagarajan P
Arnett F
Hanson CV
Paul S
Source :: AIDS (London, England) [AIDS] 2004 Jan 23; Vol. 18 (2), pp. 329-31.
Publication Year :: 2004
Abstract: A single-chain fragment containing antibody V domains (scFv) isolated from a lupus antibody library displayed the ability to bind gp120 and the conserved gp120 determinant composed of residues 421-436. The scFv neutralized R5 and X4-dependent HIV-1 strains from clades B, C, and D. The lupus repertoire may be useful as a source of neutralizing antibodies to HIV.

Subjects :: Dose-Response Relationship, Immunologic
Humans
Leukocytes, Mononuclear immunology
Epitopes immunology
HIV Envelope Protein gp120 metabolism
HIV Infections immunology
HIV-1 immunology
Immunoglobulin Fragments immunology

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