Linezolid-resistant Enterococcus faecalis isolated from a cord blood transplant recipient.

Authors :: Dibo I
Pillai SK
Gold HS
Baer MR
Wetzler M
Slack JL
Hazamy PA
Ball D
Hsiao CB
McCarthy PL Jr
Segal BH
Source :: Journal of clinical microbiology [J Clin Microbiol] 2004 Apr; Vol. 42 (4), pp. 1843-5.
Publication Year :: 2004
Abstract: We report a linezolid-resistant Enterococcus faecalis infection in a cord blood stem cell transplant recipient previously treated with linezolid for bloodstream infections by vancomycin-resistant enterococci. Sequencing showed a G2576U mutation in the 23S rRNA gene. Because of the important niche of linezolid in cancer treatment, linezolid-resistant E. faecalis is noteworthy.

Subjects :: Adult
Anti-Bacterial Agents pharmacology
Drug Resistance, Bacterial genetics
Enterococcus faecalis isolation & purification
Female
Humans
Linezolid
Microbial Sensitivity Tests
RNA, Ribosomal, 23S genetics
Sequence Analysis, DNA
Acetamides pharmacology
Anti-Infective Agents pharmacology
Enterococcus faecalis drug effects
Fetal Blood cytology
Gram-Positive Bacterial Infections microbiology
Oxazolidinones pharmacology
Stem Cell Transplantation adverse effects

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