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Catalytic asymmetric synthesis of glutamate analogues.
- Source :
-
Organic letters [Org Lett] 2004 Apr 15; Vol. 6 (8), pp. 1285-8. - Publication Year :
- 2004
-
Abstract
- Utilizing our lateral metalation coupled with Jacobsen's catalytic asymmetric amino nitrile synthesis, we have demonstrated the ability to synthesize isoxazole-containing amino acid glutamate analogues in high yield and high enantiomeric excesses. Chiral centers alpha or beta at the C-5 position do not detract from diastereoselectivity of the Jacobsen-Strecker reaction. [reaction: see text]
- Subjects :
- Animals
Binding, Competitive
Brain metabolism
Catalysis
Glutamates metabolism
Glutamates pharmacology
Isoxazoles chemistry
Mice
Models, Chemical
Neurotransmitter Agents metabolism
Neurotransmitter Agents pharmacology
Stereoisomerism
Temperature
Glutamates chemical synthesis
Neurons drug effects
Neurotransmitter Agents chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1523-7060
- Volume :
- 6
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 15070318
- Full Text :
- https://doi.org/10.1021/ol049619m