Back to Search
Start Over
Insulin-like growth factors, insulin-like growth factor-binding proteins, and endometrial cancer in postmenopausal women: results from a U.S. case-control study.
- Source :
-
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2004 Apr; Vol. 13 (4), pp. 607-12. - Publication Year :
- 2004
-
Abstract
- Objective: To assess whether circulating insulin-like growth factor-1 (IGF-1), IGF-2, insulin-like growth factor-binding protein-1 (IGFBP-1), or IGFBP-3 were associated with endometrial cancer in postmenopausal women.<br />Study Design: Between 1987 and 1990, we conducted a case-control study of 405 women with endometrial cancer and 297 matched population-based controls. This analysis included 174 postmenopausal cases and 136 controls.<br />Results: In logistic regression models adjusted for potential confounders, higher IGF-1 levels were not positively associated with endometrial cancer: odds ratio (OR) for the highest tertile versus the lowest tertile = 0.63, 95% confidence interval (CI) = 0.30-1.32. Endometrial cancer was inversely associated with IGF-2 (OR for the highest tertile = 0.35, 95% CI = 0.18-0.69) and IGFBP-3 (OR for the highest tertile = 0.40, 95% CI = 0.21-0.77), and not associated with IGFBP-1.<br />Conclusion: Serum IGF-1, IGF-2, and IGFBP-3, but not IGFBP-1, were inversely associated with endometrial cancer in postmenopausal women. These associations and the potential role of the IGF system in endometrial proliferation and carcinogenesis warrant further research.
- Subjects :
- Adult
Aged
Case-Control Studies
Endometrial Neoplasms etiology
Female
Humans
Insulin-Like Growth Factor Binding Protein 1 blood
Insulin-Like Growth Factor Binding Protein 3 blood
Insulin-Like Growth Factor Binding Proteins blood
Insulin-Like Growth Factor I metabolism
Insulin-Like Growth Factor II metabolism
Logistic Models
Middle Aged
Postmenopause
Risk Factors
United States epidemiology
Endometrial Neoplasms blood
Endometrial Neoplasms epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1055-9965
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 15066926