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Inhibition of delayed induction of p38 mitogen-activated protein kinase attenuates kainic acid-induced neuronal loss in the hippocampus.
- Source :
-
Brain research [Brain Res] 2004 May 08; Vol. 1007 (1-2), pp. 188-91. - Publication Year :
- 2004
-
Abstract
- The activation of p38 mitogen-activated protein kinase (MAPK) has been implicated in the pathological changes accompanying inflammatory and apoptotic processes of various cell types including neurons. In a kainic acid (KA)-induced mouse seizure model, p38 MAPK is induced in reactive astrocytes in the CA3 region of the hippocampus where severe neuronal loss occurs. Here we report the delayed and protracted activation of p38 MAPK in the CA3 region of the hippocampus of mice treated with KA. In this model, the inhibition of p38 MAPK isoforms by SB203580, a specific inhibitor, attenuated neuronal loss in the CA3 and CA1 regions of the hippocampus, which was accompanied by the suppression of the p38 MAPK activation as well as astrogliosis. Thus, the delayed and sustained induction of p38 MAPK plays a crucial role in the neuronal damage of KA-induced brain seizures.
- Subjects :
- Activating Transcription Factor 2
Animals
Blotting, Western
Cyclic AMP Response Element-Binding Protein metabolism
Drug Interactions
Enzyme Inhibitors pharmacology
Excitatory Amino Acid Agonists toxicity
Imidazoles pharmacology
Immunohistochemistry methods
Male
Mice
Mice, Inbred BALB C
Mitogen-Activated Protein Kinase 8
Mitogen-Activated Protein Kinases antagonists & inhibitors
Neurons cytology
Protein Isoforms pharmacology
Pyridines pharmacology
Time Factors
Transcription Factors metabolism
p38 Mitogen-Activated Protein Kinases
Cell Death drug effects
Hippocampus cytology
Kainic Acid toxicity
Mitogen-Activated Protein Kinases metabolism
Neurons drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0006-8993
- Volume :
- 1007
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 15064151
- Full Text :
- https://doi.org/10.1016/j.brainres.2004.02.009