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Differential radioprotection of tissues in C3H/J mice by a combination of 5-hydroxy L-tryptophan with 2-aminoethylisothiuronium bromide hydrobromide.
- Source :
-
Indian journal of experimental biology [Indian J Exp Biol] 1992 Jun; Vol. 30 (6), pp. 478-81. - Publication Year :
- 1992
-
Abstract
- Differential radioprotection between normal tissues and carcinoma was observed in C3H/J mice treated with a combination of 5-hydroxy L-tryptophan (5-HTP, 100 mg/kg) and 2-aminoethylisothiuronium bromide hydrobromide (AET, 20 mg/kg). Protection to normal tissues was judged by LD50(30) and by radiation induced damage to bone marrow(BM) using clonogenic ability of blood forming stem cells (10 day CFUs) as the criteria. Pretreatment with 5-HTP + AET combination 30 min before whole body gamma radiation (WBGR) enhanced the recoveries of the number of blood forming stem cells in BM of irradiated mice after 0, 7th and 10th day of irradiation. LD50(30) for C3H/J mice was 7.3 Gy and the dose modifying factor (DMF) of 5-HTP + AET combination was 1.76. On the contrary, pretreatment with this combination did not protect the mammary carcinoma transplanted in C3H/J mice, when exposed to 80 Gy soft X-rays.
- Subjects :
- Animals
Bone Marrow drug effects
Bone Marrow Cells
Cell Survival
Drug Combinations
Female
Gamma Rays
Male
Mammary Neoplasms, Experimental
Mice
Mice, Inbred C3H
Neoplastic Stem Cells cytology
Neoplastic Stem Cells drug effects
Neoplastic Stem Cells radiation effects
5-Hydroxytryptophan pharmacology
Bone Marrow radiation effects
Radiation-Protective Agents pharmacology
beta-Aminoethyl Isothiourea pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0019-5189
- Volume :
- 30
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Indian journal of experimental biology
- Publication Type :
- Academic Journal
- Accession number :
- 1506027