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Dopamine overflow is increased in olfactory bulbectomized rats: an in vivo microdialysis study.
- Source :
-
Physiology & behavior [Physiol Behav] 2004 Mar; Vol. 81 (1), pp. 111-9. - Publication Year :
- 2004
-
Abstract
- Olfactory bulbectomy (OBX) in rats produces behavioral, physiological, and neurochemical changes that resemble symptoms of depression in humans. The procedure thus serves as a rodent model of affective disorder. Many of the behavioral effects of OBX resemble psychomotor agitation. The possible role of dysregulation of ventral striatal dopamine (DA) systems in this phenomenon was investigated. Basal levels of DA, norepinephrine (NE), homovanillic acid, dihydroxyphenylacetic acid, and 5-hydroxyindoleacetic acid were examined in the striatum of OBX and sham-operated controls using in vivo microdialysis. OBX rats exhibited significantly higher basal DA levels (192%) and lower NE levels (12%) than sham-operated controls. Locomotor activity in response to novelty and footshock stress was elevated in OBX rats. The finding of higher DA levels in striatum may explain this "agitation-like" behavior, a commonly observed phenomenon in the OBX model.
- Subjects :
- 3,4-Dihydroxyphenylacetic Acid analysis
3,4-Dihydroxyphenylacetic Acid metabolism
Animals
Basal Ganglia metabolism
Disease Models, Animal
Exploratory Behavior physiology
Homovanillic Acid analysis
Homovanillic Acid metabolism
Hydroxyindoleacetic Acid analysis
Hydroxyindoleacetic Acid metabolism
Male
Microdialysis
Motor Activity physiology
Norepinephrine metabolism
Olfactory Bulb surgery
Psychomotor Agitation physiopathology
Rats
Rats, Sprague-Dawley
Stress, Psychological metabolism
Basal Ganglia chemistry
Dopamine analysis
Dopamine metabolism
Norepinephrine analysis
Olfactory Bulb physiology
Psychomotor Agitation metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0031-9384
- Volume :
- 81
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Physiology & behavior
- Publication Type :
- Academic Journal
- Accession number :
- 15059690
- Full Text :
- https://doi.org/10.1016/j.physbeh.2004.01.003