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Role of CD40 and B7 costimulators in inflammatory bowel diseases.
- Source :
-
Acta bio-medica : Atenei Parmensis [Acta Biomed] 2003; Vol. 74 Suppl 2, pp. 65-70. - Publication Year :
- 2003
-
Abstract
- We analyse the costimulating role of CD40/CD40 ligand and B7/CD28 in inflammatory bowel diseases (IBD) as a potential target of antibody therapy. CD40, expressed by lamina propria B lymphocytes in gut mucosa, interacts with CD40 ligand on T cell. This interaction is implicated in the pathogenesis of IBD. In some animal models of colitis the anti-CD40L therapy demonstrated to be effective. Phase II trials on Crohn's disease are ongoing. B7.1 and B7.2, expressed by macrophages, interact with CD28, on T cell. B7.2 resulted implicated in ulcerative colitis, determining a Th2 pattern, whereas B7.1, a major Th1 stimulator, could be involved in Crohn's disease. In some animal models of colitis anti-B7.1, but not anti-B7.2, was effective. Anti B7 therapy was not yet tested in humans.
Details
- Language :
- English
- ISSN :
- 0392-4203
- Volume :
- 74 Suppl 2
- Database :
- MEDLINE
- Journal :
- Acta bio-medica : Atenei Parmensis
- Publication Type :
- Academic Journal
- Accession number :
- 15055038