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Effect of inhibition of the Na+/H+ exchanger with cariporide on left ventricular function in acute coronary syndromes: results from the echocardiographic substudy of the GUARDIAN trial.
- Source :
-
The Canadian journal of cardiology [Can J Cardiol] 2004 Mar 01; Vol. 20 (3), pp. 317-22. - Publication Year :
- 2004
-
Abstract
- Objective: To evaluate the effects of inhibition of the Na+/H+ exchanger (NHE) on regional left ventricular dysfunction in patients with a non-ST elevation acute coronary syndrome (ACS) BACKGROUND: NHE inhibition protects against myocardial necrosis and stunning in ischemia-reperfusion models.<br />Methods and Results: In a substudy of the GUARd During Ischemia Against Necrosis (GUARDIAN) trial, 141 patients with an ACS and wall motion abnormalities on a baseline echocardiogram underwent repeated studies after 48 h and 36 days to determine the extent of early and late recovery of ventricular function. Patients were randomized to cariporide 20 mg, 80 mg or 120 mg intravenously three times per day or placebo for two to seven days. The wall motion score index improved from baseline to day 36 by 0.13+/-0.21, 0.16+/-0.34 and 0.15+/-0.28, respectively, in the cariporide groups, and by 0.10+/-0.16 with placebo (P=0.57). From baseline to 48 h, the wall motion score index decreased by 0.04+/-0.16, 0.08+/-0.20 and 0.03+/-0.22, respectively, for the cariporide groups and by 0.03+/-0.11 with placebo (P=0.09); the number of abnormal chords (centreline method) decreased by 11.2+/-24.0, 9.5+/-24.3 and 8.1+/-27.9, respectively, in the cariporide groups compared with an increase of 0.6+/-20.0 with placebo (P=NS).<br />Conclusion: No significant benefit of NHE inhibition could be detected in ACS patients in the GUARDIAN trial.
- Subjects :
- Anti-Arrhythmia Agents administration & dosage
Double-Blind Method
Echocardiography
Female
Guanidines administration & dosage
Humans
Male
Middle Aged
Myocardial Infarction diagnostic imaging
Myocardial Infarction drug therapy
Sulfones administration & dosage
Anti-Arrhythmia Agents pharmacology
Guanidines pharmacology
Myocardial Infarction physiopathology
Sodium-Hydrogen Exchangers antagonists & inhibitors
Sulfones pharmacology
Ventricular Function, Left drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0828-282X
- Volume :
- 20
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Canadian journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 15054512