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Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network.
- Source :
-
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics [Am J Med Genet B Neuropsychiatr Genet] 2004 Apr 01; Vol. 126B (1), pp. 46-50. - Publication Year :
- 2004
-
Abstract
- A recent study by Persico et al. [2001: Mol Psychiatry 6:150-159] suggests alleles of a CGG polymorphism, just 5' of the reelin gene (RELN) initiator codon, confer liability for autism, especially alleles bearing 11 or more CGG repeats (long alleles). The association is consistent across both a case-control and family-based sample. We attempted to replicate their finding using a larger, independent family-based sample from the NIH Collaborative Programs of Excellence in Autism (CPEA) Network. In our data, allele transmissions to individuals with autism versus unaffected individuals are unbiased, both when alleles are classified by repeat length and when they are classified into long/short categories. Because of the apparent linkage of autism to chromosome 7q, particularly related to the development of language, we also evaluate the relationship between Reelin alleles and the age at which autism subjects use their first word or first phrase. Neither is significantly associated with Reelin alleles. Our results are not consistent with a major role for Reelin alleles in liability to autism.<br /> (Published 2004 Wiley-Liss, Inc.)
- Subjects :
- Case-Control Studies
Humans
Linkage Disequilibrium
Nerve Tissue Proteins
Reelin Protein
Serine Endopeptidases
Alleles
Autistic Disorder genetics
Cell Adhesion Molecules, Neuronal genetics
Extracellular Matrix Proteins genetics
Genetic Predisposition to Disease
Trinucleotide Repeats genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1552-4841
- Volume :
- 126B
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 15048647
- Full Text :
- https://doi.org/10.1002/ajmg.b.20125