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[A phase I study of combination chemotherapy using TS-1 and pirarubicin (THP) for advanced gastric cancer].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2004 Mar; Vol. 31 (3), pp. 361-5. - Publication Year :
- 2004
-
Abstract
- The safety of chemotherapy combining TS-1 and pirarubicin (THP) for treatment of recurrent or locally advanced gastric cancer was evaluated. THP was administered by intravenous drip infusion at a dose of 14 mg/m2 every other week. TS-1 was administered orally at a dose of 40 mg/m2 twice a day for 2 weeks followed by 2 weeks of rest (level 1), for 3 weeks followed by 2 weeks of rest (level 2), and for 4 weeks followed by 2 weeks of rest (level 3). Three patients were treated with the level 1 schedule. One patient with peritoneal dissemination received 22 courses of the treatment, and benefited from a long-term NC. However the remaining 2 cases were diagnosed as PD after 4 courses and were withdrawn from further treatment. Two patients in this group suffered from grade 2 adverse events according to the NCI-CTC. Only 1 patient who had liver metastasis was treated at level 2. Fourteen courses were administered, and a PR was achieved while grade 2 adverse events were observed. One of 3 patients who were treated with level 3 had grade 3 adverse events. Consequently, 3 more cases were added to this dose level, and no additional grade 3 adverse events were observed, while grade 2 adverse events were seen in 4 cases. Urinary urgency had completely disappeared in 1 patient with peritoneal recurrence. Myelosuppression, which was the main observed adverse event, was well controlled and of brief duration. The response, including alleviation of clinical symptoms, was confirmed in 3 of 5 chemo-naive patients.
- Subjects :
- Adult
Aged
Anemia chemically induced
Antineoplastic Combined Chemotherapy Protocols adverse effects
Doxorubicin administration & dosage
Doxorubicin adverse effects
Drug Administration Schedule
Drug Combinations
Female
Humans
Leukopenia chemically induced
Liver drug effects
Male
Middle Aged
Nausea chemically induced
Neoplasm Recurrence, Local drug therapy
Oxonic Acid administration & dosage
Oxonic Acid adverse effects
Pyridines administration & dosage
Pyridines adverse effects
Stomach Neoplasms pathology
Tegafur administration & dosage
Tegafur adverse effects
Vomiting, Anticipatory etiology
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Doxorubicin analogs & derivatives
Stomach Neoplasms drug therapy
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 31
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 15045941