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Second-line therapy with caspofungin for mucosal or invasive candidiasis: results from the caspofungin compassionate-use study.
- Source :
-
The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2004 May; Vol. 53 (5), pp. 878-81. Date of Electronic Publication: 2004 Mar 24. - Publication Year :
- 2004
-
Abstract
- Objectives: To prospectively assess the efficacy and safety of caspofungin as second-line therapy for mucosal or invasive candidiasis in patients enrolled in the caspofungin compassionate-use study.<br />Materials and Methods: Thirty-seven patients with mucosal or invasive candida infections (17 oesophageal, four oropharyngeal and 16 invasive candidiasis) were enrolled in the caspofungin compassionate-use study. All patients were refractory to or intolerant of intravenous amphotericin B or lipid amphotericin formulation(s). Efficacy was assessed at the end of intravenous caspofungin therapy based on clinical (and, where appropriate, microbiological) response.<br />Results: HIV was the most common (91%) risk factor in patients with mucosal candidiasis; patients with invasive candidiasis commonly had acute leukaemia/lymphoma (50%) or diabetes mellitus (31%). Most patients with mucosal candidiasis (91%) and invasive candidiasis (94%) were refractory to >/=1 antifungal agent(s). A favourable response was noted in 82% (14/17) with oesophageal candidiasis, 100% (4/4) with oropharyngeal candidiasis and 87% (13/15) with invasive candidiasis. Caspofungin was generally well tolerated; one serious drug-related adverse event was reported.<br />Conclusion: In this study, caspofungin was an effective alternative for patients with refractory candida infections.
- Subjects :
- Adolescent
Adult
Aged
Antifungal Agents adverse effects
Candidiasis microbiology
Candidiasis mortality
Caspofungin
Drug Resistance, Fungal
Echinocandins
Female
HIV Infections complications
Humans
Lipopeptides
Male
Middle Aged
Neutropenia complications
Peptides adverse effects
Treatment Outcome
Antifungal Agents therapeutic use
Candidiasis drug therapy
Peptides therapeutic use
Peptides, Cyclic
Subjects
Details
- Language :
- English
- ISSN :
- 0305-7453
- Volume :
- 53
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of antimicrobial chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 15044431
- Full Text :
- https://doi.org/10.1093/jac/dkh179