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Pharmacokinetics of recombinant hirudin in healthy horses.
- Source :
-
Equine veterinary journal [Equine Vet J] 2004 Mar; Vol. 36 (2), pp. 135-41. - Publication Year :
- 2004
-
Abstract
- Reasons for Performing Study: Recombinant (r)-hirudin is a specific inhibitor of thrombin that is independent of the activity of antithrombin.<br />Objectives: To evaluate pharmacokinetic properties and coagulatory changes of r-hirudin in healthy horses.<br />Methods: Two clinically healthy horses received a single i.v. bolus of 0.4 mg/kg bwt r-hirudin and 6 clinically healthy horses received the same dose subcutaneously (subcut.) q. 12 h for 3 days. Coagulation times and r-hirudin plasma concentration were determined over 720 mins and 3 days after i.v. and subcut. administration, respectively.<br />Results: In all horses, treatment with r-hirudin was not associated with systemic or local side effects. After i.v. injection, the 2 horses showed an elimination half-life of 58 and 80 mins, respectively. After subcut. administration, maximum plasma concentration of r-hirudin occurred at 128 +/- 55 mins and declined with a terminal half-life of 561 +/- 364 mins. Maximum response of activated partial thromboplastin time (aPTT) occurred 1.5 h after administration of r-hirudin. A prolongation of 1.9 +/- 0.2 times the pretreatment value was noted.<br />Conclusions: Pharmacokinetics of r-hirudin in healthy horses were similar to those in man and other animal species.<br />Potential Relevance: The results of this study indicate that r-hirudin can be used in horses, but further studies should be performed in order to prove its effectiveness in diseased horses.
- Subjects :
- Animals
Blood Coagulation drug effects
Female
Fibrinolytic Agents administration & dosage
Fibrinolytic Agents adverse effects
Half-Life
Hirudins administration & dosage
Hirudins adverse effects
Injections, Intravenous veterinary
Injections, Subcutaneous veterinary
Male
Metabolic Clearance Rate drug effects
Partial Thromboplastin Time veterinary
Fibrinolytic Agents pharmacokinetics
Hirudins pharmacokinetics
Horses metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0425-1644
- Volume :
- 36
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Equine veterinary journal
- Publication Type :
- Academic Journal
- Accession number :
- 15038436
- Full Text :
- https://doi.org/10.2746/0425164044868666