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An age-associated decrease in the frequency of C4B*Q0 indicates that null alleles of complement may affect health or survival.
- Source :
-
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2003 Dec; Vol. 1010, pp. 496-9. - Publication Year :
- 2003
-
Abstract
- We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B(*)Q0) and C3 (C3(*)F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B(*)Q0 on health or survival.
Details
- Language :
- English
- ISSN :
- 0077-8923
- Volume :
- 1010
- Database :
- MEDLINE
- Journal :
- Annals of the New York Academy of Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 15033778
- Full Text :
- https://doi.org/10.1196/annals.1299.091